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Checking the Medicine Cabinet to Interrupt COVID-19 at the Molecular Level

In the face of the COVID 19 pandemic, a Massachusetts biotech startup turns to the MGHPCC for HPC resources in its hunt for existing FDA-approved drugs that might be a therapeutic candidate against the novel coronavirus. 

Joy Alamgir is an entrepreneur based in Massachusetts currently pursuing ideas in biotechnology with a computational focus under the umbrella Alamgir Research Inc. Using high-performance computing to perform picometer-scale molecular modeling, his company simulates how key proteins COVID 19 uses to propagate behave in the presence of existing FDA-approved therapies. Viruses replicate by entering cells and commandeering their reproductive machinery. SARS-CoV-2 makes multiple proteins to propagate. If these proteins can be safely and effectively targeted, then viral activity and replication can be inhibited, resulting in reduced disease severity.

Joy Alamgir
Entrepreneur and C3DDB user

Research projects

Dusty With a Chance of Star Formation
Checking the Medicine Cabinet to Interrupt COVID-19 at the Molecular Level
Not Too Hot, Not Too Cold But Still, Is It Just Right?​
Smashing Discoveries​
Microbiome Pattern Hunting
Modeling the Air we Breathe
Exploring Phytoplankton Diversity
The Computer Will See You Now
Computing the Toll of Trapped Diamondback Terrapins
Edging Towards a Greener Future
Physics-driven Drug Discovery
Modeling Plasma-Surface Interactions
Sensing Subduction Zones
Neural Networks & Earthquakes
Small Stars, Smaller Planets, Big Computing
Data Visualization using Climate Reanalyzer
Getting to Grips with Glassy Materials
Modeling Molecular Engines
Forest Mapping: When the Budworms come to Dinner
Exploring Thermoelectric Behavior at the Nanoscale
The Trickiness of Talking to Computers
A Genomic Take on Geobiology
From Grass to Gas
Teaching Computers to Identify Odors
From Games to Brains
The Trouble with Turbulence
A New Twist
A Little Bit of This... A Little Bit of That..
Looking Like an Alien!
Locking Up Computing
Modeling Supernovae
Sound Solution
Lessons in a Virtual Test Tube​
Higgs Boson Spotted in Holyoke?
Crack Computing
Automated Real-time Medical Imaging Analysis
Towards a Smarter Greener Grid
Heading Off Head Blight
Organic Light-Harvesting Antennae
Art and AI
Excited by Photons
Tapping into an Ocean of Data
All Research Projects

Collaborative projects

ALL Collaborative PROJECTS

Outreach & Education Projects

ALL OUTREACH & Education PROJECTS
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