Big Data, Big Computation and the Genomic Jigsaw Puzzle

November 4, 2012

The second video in our series profiling MGHPCC seed fund collaborations
by Helen Hill
The human genome is made up of 3 billion base pairs. Reading the genome from a modern, high-speed sequencer is a lot like doing a big jigsaw puzzle. Computer Scientist, Assistant Professor Yanlei Diao (UMass Amherst) is leading a multi institution collaboration to develop next-generation, on-demand big computation services for managing and processing these massive amounts of genomic information.

Working with Li-Jun Ma, Assistant Professor in Plant, Soil and Insect Sciences (UMass Amherst), Professor Samuel Madden (MIT), Bai-Lin Wu (Harvard and Children's Hospital), Toby Bloom (the Broad Institute of Harvard and MIT), and James F. Gusella (Massachusetts General Hospital), Diao's project was one of 7 to receive seed funding, in the first round of such awards from the Massachusetts Green High Performance Computing Consortium in 2011.

In this video members of the team share the science behind their work, what each brings to the project as well as what harnessing high performance computing could bring to genomics, epigenomics and human health.
Thanks to the staff of the Genetics Diagnostic Lab at Children's Hospital, Boston for their help in making this video.

Research projects

Dusty With a Chance of Star Formation
Checking the Medicine Cabinet to Interrupt COVID-19 at the Molecular Level
Not Too Hot, Not Too Cold But Still, Is It Just Right?​
Smashing Discoveries​
Microbiome Pattern Hunting
Modeling the Air we Breathe
Exploring Phytoplankton Diversity
The Computer Will See You Now
Computing the Toll of Trapped Diamondback Terrapins
Edging Towards a Greener Future
Physics-driven Drug Discovery
Modeling Plasma-Surface Interactions
Sensing Subduction Zones
Neural Networks & Earthquakes
Small Stars, Smaller Planets, Big Computing
Data Visualization using Climate Reanalyzer
Getting to Grips with Glassy Materials
Modeling Molecular Engines
Forest Mapping: When the Budworms come to Dinner
Exploring Thermoelectric Behavior at the Nanoscale
The Trickiness of Talking to Computers
A Genomic Take on Geobiology
From Grass to Gas
Teaching Computers to Identify Odors
From Games to Brains
The Trouble with Turbulence
A New Twist
A Little Bit of This... A Little Bit of That..
Looking Like an Alien!
Locking Up Computing
Modeling Supernovae
Sound Solution
Lessons in a Virtual Test Tube​
Crack Computing
Automated Real-time Medical Imaging Analysis
Towards a Smarter Greener Grid
Heading Off Head Blight
Organic Light-Harvesting Antennae
Art and AI
Excited by Photons
Tapping into an Ocean of Data
Computing Global Change
Star Power
Engineering the Human Microbiome
Computing Social Capital
Computers Diagnosing Disease
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Collaborative projects

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Outreach & Education Projects

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