The MGHPCC is providing a world-class computational infrastructure, indispensible in the increasingly sensor and data-rich environments of modern science and engineering discovery. Today, virtually no major breakthrough, be it designing a new drug, developing new materials for clean energy or addressing climate change -- can take place without computation. In silico experimentation adds a powerful new dimension to knowledge discovery in all fields, alongside theory, physical experimentation and observation. With the increasingly integrated role of computation in fundamental and applied research, the MGHPCC represents a critical piece of infrastructure that will continue to fuel the world-leading innovation economy of the Commonwealth of Massachusetts through cooperative research, education and outreach activities.