Research in Miriam E. Leeser's Reconfigurable and GPU Computing Laboratory (RCL) is centered on the use of hardware accelerators such as Field Programmable Gate Arrays (FPGAs) and Graphics Processing Units (GPUs) for a wide variety of applications. Researchers in the lab seek to develop tools, libraries, and interfaces that make accelerators easier to use. Their work helps speed up wireless networking, IoT, medical imaging, security and privacy applications, in many cases taking theoretical algorithm advances and making them practically viable for the first time.

A key project is The Open Cloud Testbed (OCT) which seeks to construct and support a testbed for research and experimentation into new cloud platforms.